epitope mapping within an internal region of ZNF276 of human origin
recommended for detection of ZNF276 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with other ZNF family members
ZNF276 Background Information Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF276 is a 614 amino acid protein containing five C2H2-type zinc fingers and one zinc finger associated (ZAD) domain. Due to a loss of heterozygosity at the chromosomal location of the gene encoding ZNF276 in sporadic breast cancers, the ZNF276 gene has been targeted as a possible breast cancer tumor suppressor. The FANCA gene, which encodes a DNA repair protein, is situated at the same chromosomal location as the ZNF276 gene, suggesting a possible involvement of ZNF276 in the progression of Fanconi anemia, an autosomal recessive disorder which is caused by mutations in the gene encoding FANCA. There are two isoforms of ZNF276 that exist as a result of an alternative splicing event.
ZNF276 (K-13)
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ZNF276 (K-13): sc-132165. Western blot analysis of ZNF276 expression in non-transfected: sc-117752 (A) and human ZNF276 transfected: sc-178164 (B) 293T whole cell lysates.
