 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of IDS of human origin
- recommended for detection of IDS isoforms Long and Short of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and porcine
- blocking peptide, sc-131558 P
|
|
| |
Informacoes sobre ordens
Produtos Auxiliares Recomendados
(clique na sua escolha)
IDS Background Information
IDS (Iduronate 2-sulfatase), also known as SIDS, is a 550 amino acid protein that localizes to the lysosome and belongs to the sulfatase family. Expressed in lung, liver, kidney and placenta, IDS uses calcium as a cofactor to catalyze the hydrolysis of select sulfate groups on dermatan sulfate, heparan sulfate and heparin and, via this catalytic activity, is essential for the lysosomal degradation of both dermatan and heparan sulfate. Defects in the gene encoding IDS are the cause of mucopolysaccharidosis type 2 (MPS2), more commonly known as Hunter syndrome, which is characterized by skeletal deformities, hepatosplenomegaly and progressive cardiopulmonary deterioration, as well as neurological damage and, in some cases, death. IDS exists as two alternatively spliced isoforms, designated long and short. |
|
|
IDS (S-14)
Clique na imagem para aumenta-la
|
IDS (S-14): sc-131558. Western blot analysis of IDS expression in non-transfected: sc-110760 (A) and mouse IDS (S-14) transfected: sc-178771 (B) 293 whole cell lysates. |
|
baixar arquivo
|
|
