CD138/SDC1/Syndecan-1 Antibody (DL-101): sc-12765

Syndecan-1 Antibody (DL-101) is a mouse monoclonal IgG1 kappa light chain antibody that detects Syndecan-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Syndecan-1 (DL-101) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syndecan-1 (SYND1), also known as CD138, is a type I integral membrane proteoglycan that plays a crucial role in cell signaling and adhesion due to its ability to interact with components of the extracellular matrix, such as collagens, fibronectin, and thrombospondin. Syndecan-1 is predominantly expressed on pre-B cells, immature B cells, and plasma cells in mice, as well as on the basolateral surfaces of epithelial cells, endothelial cells in sprouting capillaries, and embryonic condensing mesenchymal cells. Syndecan-1 presence on these cell types is vital for maintaining tissue architecture and facilitating cellular communication, as Syndecan-1 helps to anchor cells to the extracellular matrix and may influence cell migration and proliferation. Additionally, Syndecan-1 has been shown to co-localize with actin-rich filaments, suggesting Syndecan-1′s role in linking the cytoskeleton to the extracellular matrix, which is essential for maintaining cellular integrity and function.

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CD138/SDC1/Syndecan-1 Antibody (DL-101) References:

1. Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans.  |  Bernfield, M., et al. 1992. Annu Rev Cell Biol. 8: 365-93. PMID: 1335744
2. B lymphocytes express and lose syndecan at specific stages of differentiation.  |  Sanderson, RD., et al. 1989. Cell Regul. 1: 27-35. PMID: 2519615
3. Syndecan-1 in Liver Diseases.  |  Regős, E., et al. 2020. Pathol Oncol Res. 26: 813-819. PMID: 30826971
4. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.  |  Yao, W., et al. 2019. Nature. 568: 410-414. PMID: 30918400
5. Syndecan-1 in the Tumor Microenvironment.  |  Handra-Luca, A. 2020. Adv Exp Med Biol. 1272: 39-53. PMID: 32845501
6. Syndecan-1 (CD138), Carcinomas and EMT.  |  Couchman, JR. 2021. Int J Mol Sci. 22: PMID: 33921767
7. Syndecan-1 in liver pathophysiology.  |  Reszegi, A., et al. 2022. Am J Physiol Cell Physiol. 323: C289-C294. PMID: 35704700
8. Cell surface syndecan-1 on distinct cell types differs in fine structure and ligand binding of its heparan sulfate chains.  |  Kato, M., et al. 1994. J Biol Chem. 269: 18881-90. PMID: 8034644
9. Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.  |  Kokenyesi, R. and Bernfield, M. 1994. J Biol Chem. 269: 12304-9. PMID: 8163535
10. Integral membrane heparan sulfate proteoglycans.  |  David, G. 1993. FASEB J. 7: 1023-30. PMID: 8370471
11. The cytoplasmic domain of syndecan-1 is required for cytoskeleton association but not detergent insolubility. Identification of essential cytoplasmic domain residues.  |  Carey, DJ., et al. 1996. J Biol Chem. 271: 15253-60. PMID: 8662979
12. Syndecans, signaling, and cell adhesion.  |  Couchman, JR. and Woods, A. 1996. J Cell Biochem. 61: 578-84. PMID: 8806081

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD138/SDC1/Syndecan-1 Antibody (DL-101) has 71 citations in a variety of scientific publications.

Primary antibodies like Anti-CD138/SDC1/Syndecan-1 Antibody (DL-101) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD138/SDC1/Syndecan-1 Antibody (DL-101) Specifications

Alternate Product Name: Syndecan-1

Product Clone Name: DL-101

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Syndecan-1

Epitope Species: human

Product Reactivity/Detection: the ectodomain of Syndecan-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 71 citations in various scientific publications

Available Conjugates/Forms for CD138/SDC1/Syndecan-1 Antibody (DL-101): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin