epitope mapping near the N-terminus of KV4.3 of human origin
recommended for detection of KV4.3 long and short forms of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
KV4.3 Background Information Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å-subunits (KVå), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV∫ subunits that modify the gating properties of the coexpressed KVå subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.
KV4.3 (N-15) Citacoes dos Produtos
Veja como outros autores utilizaram o anticorpo e/ou o anticorpo cojugado
