epitope mapping at the C-terminus of Katanin p80 B1 of human origin
recommended for detection of Katanin p80 B1 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with family members Katanin p60 A1, Katanin p60 AL1 or Katanin p60 AL2 ; also reactive with additional species, including equine, bovine and avian
Katanin p80 B1 Background Information Microtubules are polymers of alpha and beta subunits that form the mitotic spindle and assist in the organization of membranous organelles during interphase. Katanin is a heterodimer complex that severs microtubules in an ATP-dependent manner. The severing of microtubules by the Katanin complex may promote reorganization of cellular microtubule arrays and release of microtubules from the centrosome following nucleation. The Katanin complex is composed of a 60 kDa subunit (Katanin p60 A1) and a 80 kDa accessory protein (Katanin p80 B1). Katanin p60 A1 is responsible for the severing and disassembly of microtubules, while Katanin p80 B1 targets the complex to the centrosome.
