MAGE-A8 Background Information The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types, but not in normal tissues, with the exception of testis and placenta. Although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their function in normal cells remains unknown. MAGE-A8 appears to be overexpressed in a majority of human bladder carcinomas.
MAGE-A8 (V-25)
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MAGE-A8 (V-25): sc-102016. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing nuclear and cytoplasmic staining.
MAGE-A8 (V-25): sc-102016. Western blot analysis of MAGE-A8 expression in placenta tissue extract.
