Pleckstrin Antibody (227.1): sc-100813
- Pleckstrin Antibody (227.1) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant Pleckstrin of human origin
- recommended for detection of Pleckstrin of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Pleckstrin Antibody (227.1) for WB and IHC(P) applications. This reagent is now offered in a bundle with Pleckstrin Antibody (227.1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Pleckstrin Antibody (227.1) is a mouse monoclonal IgG2a antibody that detects pleckstrin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Pleckstrin plays a crucial role in platelet activation and inflammatory responses, acting as a major substrate for protein kinase C (PKC) phosphorylation. Pleckstrin is primarily located in the cytoplasm of platelets and neutrophils, where rapid phosphorylation occurs upon stimulation by inflammatory signals. Phosphorylation of pleckstrin at specific serine residues induces a conformational change that enhances interaction with cellular membranes and the cytoskeleton, thereby facilitating recruitment of proteins and lipids essential for microbicidal response. Pleckstrin homology domains within pleckstrin′s structure allow for specific protein-protein and protein-lipid interactions, which are vital for signaling pathways that lead to effective immune responses. With significant role in mediating cellular responses to inflammation, anti-pleckstrin antibody (227.1) serves as an invaluable tool for researchers studying platelet function and immune system dynamics.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pleckstrin Antibody (227.1) | sc-100813 | 100 µg/ml | $339.00 | |||
Pleckstrin Antibody (227.1): m-IgGκ BP-HRP Bundle | sc-521184 | 100 µg Ab, 40 µg BP | $361.00 |