Molecular structure of 16-Dehydropregnenolone, CAS Number: 1162-53-4
16-Dehydropregnenolone (CAS 1162-53-4)
Alternate Names:
3 β-Hydroxy-5,16-pregnadien-20-one
CAS Number:
1162-53-4
Molecular Weight:
314.50
Molecular Formula:
C21H30O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
16-Dehydropregnenolone is a white crystalline substance that doesn′t dissolve in water but is soluble in organic mediums like ethanol and chloroform. This compound serves as a precursor material to other steroid hormones, including androstenedione, testosterone, and estrone. In scientific research, it′s used to inhibit the activity of the 17-β hydroxysteroid dehydrogenase enzyme. Additionally, it′s used as a standard in HPLC and GC-MS techniques to identify and measure estradiol and estrone levels in biological samples.
16-Dehydropregnenolone (CAS 1162-53-4) References
- HPLC-UV method development and validation for 16-dehydropregnenolone, a novel oral hypolipidaemic agent, in rat biological matrices for application to pharmacokinetic studies. | Singh, SK., et al. 2003. J Pharm Biomed Anal. 33: 755-64. PMID: 14623602
- A sensitive and selective HPLC/ESI-MS/MS assay for the simultaneous quantification of 16-dehydropregnenolone and its major metabolites in rabbit plasma. | Suryawanshi, S., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 830: 54-63. PMID: 16290073
- Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats. | Suryawanshi, S., et al. 2011. J Pharm Pharmacol. 63: 41-8. PMID: 21155814
- Aza-annulation on the 16-dehydropregnenolone, via tandem intermolecular aldol process and intramolecular Michael addition. | Kumar, M., et al. 2011. Bioorg Med Chem Lett. 21: 2232-7. PMID: 21435872
- Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-Dehydropregnenolone. | Kumar, D., et al. 2012. Indian J Pharmacol. 44: 57-62. PMID: 22345871
- Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells. | Ma, EL., et al. 2012. J Asian Nat Prod Res. 14: 817-25. PMID: 22694166
- Pharmacokinetics and tissue distribution study of 16-dehydropregnenolone liposome in female mice after intravenous administration. | Deng, Z., et al. 2016. Drug Deliv. 23: 2787-2795. PMID: 26366505
- Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes. | Ramakrishna, R., et al. 2016. J Steroid Biochem Mol Biol. 163: 183-92. PMID: 27224941
- Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration. | Sun, Y., et al. 2017. Pharm Dev Technol. 22: 218-228. PMID: 27269370
- 16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters. | Ramakrishna, R., et al. 2017. J Steroid Biochem Mol Biol. 168: 110-117. PMID: 28232149
- Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats. | Yang, HY., et al. 2011. J Pharm Anal. 1: 135-138. PMID: 29403692
- Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals. | Feng, J., et al. 2022. ChemSusChem. 15: e202102399. PMID: 35089653
- Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells. | Scherbakov, AM., et al. 2023. Invest New Drugs. 41: 142-152. PMID: 36695998
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
16-Dehydropregnenolone, 10 mg | sc-287310B | 10 mg | $35.00 | |||
16-Dehydropregnenolone, 1 g | sc-287310 | 1 g | $74.00 | |||
16-Dehydropregnenolone, 5 g | sc-287310A | 5 g | $295.00 |