epitope mapping near the C-terminus of ZCCHC2 of human origin
recommended for detection of ZCCHC2 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with ZCCHC11; also reactive with additional species, including equine, canine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-85222 X, 100 µg/0.1 ml
ZCCHC2 Background Information Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZCCHC2 (zinc finger CCHC domain-containing protein 2) is a 1178 amino acid protein that contains one CCHC-type zinc finger, suggesting a role in transcriptional regulation. The gene encoding ZCCHC10 maps to human chromosome 18, which encodes over 300 genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, and erythropoietic protoporphyria. Translocation between chromosome 18 and 14 is also the most common translocation in cancers and occurs in follicular lymphomas.
