santa cruz biotechnology, inc.
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- mouse monoclonal IgG1, 100 µg/ml
- raised against recombinant PAFAH1B3 of human origin
- recommended for detection of PAFAH1B3 of mouse and human origin by WB, IP, IF and ELISA
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Conditions Générales
Accessoires recommandés:
(Cliquez sur l'application voulue)
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| Espèce |
Nom du Gène |
Gene ID |
Localisation chromosomique |
Numéro d'accession de l'isoforme (ARNm) |
Numéro d'accession de la protéine |
Numéro OMIM™ |
| Humain |
PAFAH1B3 |
5050 |
19q13.2 |
NM_002573 |
Q15102
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603074 |
| Souris |
Pafah1b3 |
18476 |
7 A3 |
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Q61205
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Non disponible |
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PAFAH1B3 Background Information
The platelet activating factor (PAF) acetylhydrolases catalyze hydrolysis of the sn-2 ester bond of PAF and related pro-inflammatory phospholipids and thus attenuate their bioactivity. The family of PAF acetylhydrolases includes one secreted plasma isozyme and two intracellular isozymes. The intracellular isozymes are distinguished by differences in their primary sequence, tissue localization, subunit composition and substrate preferences. The most thoroughly characterized intracellular isoform, PAFAH1B, is a heterotrimeric protein expressed in brain tissue and plays and important role in brain development and function. PAFAH1B is comprised of a regulatory subunit (LIS1) and two homologous (63% identity) catalytic subunits (PAFAH1B2 and PAFAH1B3), which harbor all the activity of the enzyme. The PAFAH1B2 and PAFAH1B3 subunits readily associate with very high affinity to form heterodimers, and this dimerization is essential for both stability and catalytic activity. PAFAH1B3 is also commonly known as PAFAH1B 29kDa subunit, PAFAH1B subunit © or PAFAH1B subunit å1. |
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PAFAH1B3 (37-K)
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PAFAH1B3 (37-K): sc-81950. Western blot analysis of PAFAH1B3 expression in IMR-32 whole cell lysate.
PAFAH1B3 (37-K): sc-81950. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing cytoplasmic localization.
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