p-ErbB2/HER2 Antibody (19G5): sc-81528

p-Neu Antibody (19G5) is a mouse monoclonal IgG1 antibody that detects Neu in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-p-Neu antibody (19G5) specifically recognizes phosphorylated forms of Neu, which is crucial for understanding cellular signaling pathways. Neu, also known as HER2, is a member of the ErbB family of receptor tyrosine kinases and plays a significant role in cell proliferation and differentiation. Neu is primarily located at the cell membrane, where interactions with various ligands and other proteins facilitate critical signaling cascades that regulate cell growth and survival. Aberrant activation of Neu through phosphorylation can lead to oncogenic signaling, contributing to the development of aggressive cancers, including breast, gastric, and esophageal tumors. Phosphorylation of Neu at specific tyrosine residues, such as Tyr 1248, promotes recruitment of signaling proteins like GRB2 and Shc, which are essential for transducing extracellular signals into cellular responses. Using p-Neu monoclonal antibody (19G5) in research can provide valuable insights into mechanisms of Neu-mediated signaling and implications in cancer biology.

The preferred antibody is Antibody (): sc-8.