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- mouse monoclonal IgG1, 50 µg/0.5 ml
- raised against synthetic phosphopeptide surrounding serine 138 of Bcl10 of human origin
- recommended for detection of Ser 138 phosphorylated Bcl10 of mouse and, to a lesser extent, human origin by WB
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Conditions Générales
Accessoires recommandés:
(Cliquez sur l'application voulue)
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| Espèce |
Nom du Gène |
Gene ID |
Localisation chromosomique |
Numéro d'accession de l'isoforme (ARNm) |
Numéro d'accession de la protéine |
Numéro OMIM™ |
| Humain |
BCL10 |
8915 |
1p22.3 |
NM_003921 |
O95999
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603517 |
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p-Bcl10 Background Information
Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NF˚B activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NF˚B activation. Overexpression of Bcl10 has been shown to induce apoptosis in a manner dependent on CARD-mediated oligomerization. Bcl10 has also been shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas. |
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p-Bcl10 (6D3)
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p-Bcl10 (6D3): sc-81484. Western blot analysis of Bcl10 phosphorylation in non-transfected: sc-117752 (A) and mouse Bcl10 transfected: sc-118789 (B) 293T whole cell lysates. p-Bcl10 (6D3): sc-81484. Western blot analysis of Bcl10 phosphorylation in serum starved SW480 (A), SW620 (B), HT29 (C), MCF7 (D), MDA-MB-231 (E) and T-47D (F) whole cell lysates.
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