CLCP1 Background Information
CLCP1 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1), also known as DCBLD2 (discoidin, CUB and LCCL domain containing 2) or ESDN, is a 775 amino acid single-pass type I membrane protein that contains one CUB domain, one LCCL domain and one F5/8 type C domain. Expressed at high levels in heart, testis and skeletal muscle, CLCP1 is thought to regulate vascular smooth muscle cell (VSMC) proliferation and remodeling and may be involved in the transformation and metastasis of various cancers, such as metastatic lung cancer and gastric carcinoma. Two isoforms of CLCP1 exist due to alternative splicing events. The gene encoding CLCP1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
