STS-1 (N-20) Anticorps: sc-69337

STS-1 Background Information
STS-1 (suppressor of T cell receptor signaling 1), also known as UBASH3B (ubiquitin associated and SH3 domain containing, B) or p70 (Cbl-interacting protein p70), is a member of the suppressor of TCR (T cell receptor) signaling family of proteins and negatively regulates signaling pathways downstream of the TCR. Localizing to the cytoplasm and nucleus, STS-1 is widely ex-pressed with little to no expression in pancreas, ovary and heart. STS-1 contains an N-terminal UBA domain, one SH3 domain and a C-terminal domain that is similar to the catalytic domain found in phosphoglycerate mutases. STS-1 exhibits phosphatase activity and is recognized as a Cbl-interacting protein. Upon ligand binding, STS-1 is recruited to activated EGFR complexes and prevents the endocytosis of EGFR by inhibiting receptor internalization and reducing the number of endocytic vesicles containing EGFR. STS-1 is also capable of inhibiting the endocytosis of PDGFR, suggesting a role for STS-1 in regulating receptor tyrosine kinase endocytosis and controlling growth factor-induced cellular functions.