epitope mapping near the C-terminus of Rab 18 of human origin
recommended for detection of Rab 18 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Rab 18 Background Information The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 18 is a 206 amino acid protein that is lipid-anchored to the cytoplasmic side of the cell membrane and belongs to the Rab subfamily of small GTPases. Expressed ubiquitously, Rab 18 plays a role in apical recycling and endocytosis and is also thought to be involved in protein transport between early endosomes and the plasma membrane.
