E-cadherin Antibody (DECMA-1): sc-59778

E-cadherin Antibody (DECMA-1) is a rat monoclonal IgG1 antibody that detects E-cadherin in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-E-cadherin antibody (DECMA-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. E-cadherin plays a crucial role in cell adhesion, acting as a key mediator of cell-cell interactions that are essential for maintaining tissue integrity and facilitating morphogenetic processes. E-cadherin is primarily located at the adherens junctions of epithelial cells, where E-cadherin forms homophilic interactions with neighboring E-cadherin molecules, thereby promoting strong adhesion between cells. Proper localization and function of E-cadherin are vital for the maintenance of epithelial tissue architecture, and dysregulation is often associated with various pathological conditions, including cancer metastasis. Classical cadherins, including E-cadherin, are characterized by large extracellular domains, which contain multiple homologous repeats that contribute to adhesive properties. E-cadherin′s intracellular domain interacts with cytoplasmic proteins such as β-catenin, linking E-cadherin to the actin cytoskeleton and playing a significant role in signaling pathways that regulate cell behavior.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-E-cadherin Antibody (DECMA-1) has 65 citations in a variety of scientific publications.

Primary antibodies like Anti-E-cadherin Antibody (DECMA-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

E-cadherin Antibody (DECMA-1) Specifications

Alternate Product Name: CDH1

Product Clone Name: DECMA-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: E-cadherin

Epitope Species: mouse

Product Reactivity/Detection: E-cadherin

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 65 citations in various scientific publications

Available Conjugates/Forms for E-cadherin Antibody (DECMA-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred E-cadherin antibody is E-cadherin Antibody (G-10): sc-8426.