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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of DNA pol β of human origin
- recommended for detection of DNA pol β by mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
- blocking peptide, sc-5927 P
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Conditions GénéralesRéférences bibliographiques
Accessoires recommandés:
(Cliquez sur l'application voulue)
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| Espèce |
Nom du Gène |
Gene ID |
Localisation chromosomique |
Numéro d'accession de l'isoforme (ARNm) |
Numéro d'accession de la protéine |
Numéro OMIM™ |
| Humain |
POLB |
5423 |
8p11.21 |
NM_002690 |
P06746
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174760 |
| Souris |
Polb |
18970 |
8 A2 |
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Q8K409
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Non disponible |
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DNA pol β Background Information
DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol å, ∫, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).
| DNA pol β (K-16) Références bibliographiques |
Consulter les citations pour ces anticorps DNA pol β (K-16): sc-5927 et/ou un anticorps DNA pol β (K-16) conjugué.
2 total citations En chargeant des citations.
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DNA pol β (K-16)
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DNA pol β (K-16): sc-5927. Western blot analysis of DNA pol β expression in Jurkat (A) and NIH/3T3 (B) nuclear extracts.
DNA pol β (K-16): sc-5927. Western blot analysis of DNA pol β expression in non-transfected 293T: sc-117752 (A) and human DNA pol β transfected 293T: sc-111735 (B) whole cell lysates and Jurkat nuclear extract (C). |
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