epitope mapping at the C-terminus of IDH3B of mouse origin
recommended for detection of IDH3B of mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
IDH3B Background Information IDH3B (Isocitrate dehydrogenase 3 (NAD+) b, NAD(+)-specific ICDH) is a 384 amino acid protein encoded by the human gene IDH3B. IDH3B belongs to the isocitrate and isopropylmalate dehydrogenases family and can bind one magnesium or manganese ion per subunit. It is usually found in the mitochondrion as a heterooligomer of subunits a, b, and g in the apparent ratio of 2:1:1. Human NAD-dependent isocitrate dehydrogenase (IDH) is allosterically activated by ADP by lowering the Km for isocitrate. NAD-dependent isocitrate dehydrogenase is a tricarboxylic acid cycle enzyme that produces 2-oxoglutarate, an organic acid required by the glutamine synthetase/glutamate synthase cycle to assimilate ammonium.
IDH3B (M-17)
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IDH3B (M-17): sc-55674. Western blot analysis of IDH3B expression in c4 whole cell lysate (A) and mouse embryo tissue extract (B).
