ICAM-1/CD54 Antibody (YN1/1.7.4): sc-52553

ICAM-1 Antibody (YN1/1.7.4) is a rat monoclonal IgG2b antibody raised against NS-1 cells of mouse origin, demonstrating reactivity with mouse species. ICAM-1 monoclonal antibody (YN1/1.7.4) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. Structurally, ICAM-1 consists of five extracellular immunoglobulin-like domains, a single transmembrane domain, and a short cytoplasmic tail. These multiple immunoglobulin-like domains are crucial for binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), facilitating cell-cell adhesion during immune responses. ICAM-1′s structure enables precise interactions necessary for leukocyte adhesion and transmigration across the endothelium during inflammation. Alterations in ICAM-1 structure or expression can impact immune surveillance and are associated with various pathological conditions, including autoimmune diseases and cancer metastasis. Understanding ICAM-1′s structural features is essential for research into its role in immune regulation and potential therapeutic interventions. Anti-ICAM-1 antibody (YN1/1.7.4) provides a valuable tool for studying the structure-function relationships of ICAM-1 in physiological and pathological processes.

The preferred ICAM-1/CD54 antibody is ICAM-1/CD54 Antibody (G-5): sc-8439.