epitope mapping within an internal region of XPLAC of human origin
recommended for detection of XPLAC of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
XPLAC Background Information Kell and XK are two covalently linked plasma membrane proteins that constitute the Kell blood group system, a group of antigens on the surface of red blood cells that are important determinants of blood type and targets for autoimmune or alloimmune diseases. XK is a 444 amino acid protein that spans the membrane 10 times and carries the ubiquitous antigen, Kx, which determines blood type. XK also plays a role in the sodium-dependent membrane transport of oligopeptides and neutral amino acids. XPLAC is a 462 amino acid member of the XK family that is expressed mostly in placenta and adrenal gland. The XPLAC gene is located on the X chromosome at position q22.1.
