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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the C-terminus of PIG-A of human origin
- recommended for detection of PIG-A isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, porcine and avian
- blocking peptide, sc-49481 P
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Conditions Générales
Accessoires recommandés:
(Cliquez sur l'application voulue)
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| Espèce |
Nom du Gène |
Gene ID |
Localisation chromosomique |
Numéro d'accession de l'isoforme (ARNm) |
Numéro d'accession de la protéine |
Numéro OMIM™ |
| Humain |
PIGA |
5277 |
Xp22.2 |
NM_002641, NM_020473 |
P37287
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311770 |
| Souris |
Piga |
18700 |
X F5 |
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Q64323
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Non disponible |
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PIG-A Background Information
Phosphatidylinositol-glycans (PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs are crucial for the synthesis of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI), a very early intermediate in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. Phospha-tidylinositol glycan class A (PIG-A), an endoplasmic reticulum (ER) transmembrane protein, contains a large cytoplasmic domain, which displays homology to the bacterial GlcNAc transferase RfaK, and a small lumenal domain, which plays a role in targeting the PIG-A protein to the rough ER. PIG-A associates with PIG-C, PIG-H, PIG-P and PIG-Q, as well as DPM2, and interacts directly with PIG-Y. Defects in PIG-A cause paroxysmal nocturnal hemoglobinuria (PNH), an acquired genetic hematologic disorder. |
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PIG-A (C-17)
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PIG-A (C-17): sc-49481. Western blot analysis of PIG-A expression in non-transfected 293T: sc-117752 (A), human PIG-A transfected 293T: sc-115388 (B) and HeLa (C) whole cell lysates. |
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