epitope mapping at the N-terminus of VAP-B/C of mouse origin
recommended for detection of VAP-B/C of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
VAP-B/C Background Information SNARES are compartmentally specific, integral membrane proteins that are involved in the fusion of membranes and the transport of intracellular proteins. SNAREs are expressed at high levels in all cell types. VAMP-associated proteins (VAPs) regulate the activity of SNARES. VAP-B is a 243 amino acid protein, which consists of a conserved N-terminal domain, an alpha-helical coiled-coil domain, and a C-terminal transmembrane domain. VAP-C is a 99 amino acid protein that is a splice variant of VAP-B and retains the N-terminal 70 residues, but lacks both the coiled-coil and the transmembrane domains. Mutations in this “VAP-B/C” gene may result in amyotrophic lateral sclerosis, pinal muscular atrophy, progressive bulbar palsy, or primary lateral sclerosis. These are all motor neuron diseases, which belong to a group of neurodegenerative disorders that involve the upper and/or lower motor neurons.
