Gab 3 Background Information The Gab (GRB2-associated binder)/DOS ('Daughter of Sevenless') (Gab) family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).
Gab 3 (H-300)
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Gab 3 (H-300): sc-33568. Western blot analysis of Gab 3 expression in non-transfected: sc-117752 (A) and human Gab 3 transfected: sc-128670 (B) 293T whole cell lysates and rat spleen tissue extract (C).
