epitope mapping within an internal region of FBP2 of rat origin
recommended for detection of FBP2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, porcine and avian
blocking peptide, sc-33032 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-33032 X, 200 µg/0.1 ml
FBP2 Background Information Activation of FUSE, the far-upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein or Far upstream element binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
