Dematin Background Information
Caldesmon, Filamin 1, Nebulin, Villin, Plastin, ADF, Gelsolin, Dematin, and Cofilin are differentially expressed Actin binding proteins. Dematin is a bundling protein of the erythrocyte membrane skeleton. Dematin is localized to the spectrin-Actin junctions, and its Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase. It may also play a role in the regulation of cell shape, implying a role in tumorigenesis. Dematin is a trimeric protein containing two identical subunits and a larger subunit.
It is localized to the heart, brain, lung, skeletal muscle and kidney. The Dematin gene located on human chromosome 8p21, a region frequently deleted in prostate cancer, and mouse chromosome 14.
