Molecular structure of L-Alanyl-L-1-aminoethylphosphonic acid, CAS Number: 60668-24-8
L-Alanyl-L-1-aminoethylphosphonic acid (CAS 60668-24-8)
Alternate Names:
Alafosfalin
Application:
L-Alanyl-L-1-aminoethylphosphonic acid is an antibacterial agent
CAS Number:
60668-24-8
Purity:
≥95%
Molecular Weight:
196.14
Molecular Formula:
C5H13N2O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Alanyl-L-1-aminoethylphosphonic acid exhibits antibacterial activity. L-Alanyl-L-1-aminoethylphosphonic acid, also known as AEP or Ala-AEP, is a synthetic peptide derivative. It is an amino acid analogue that contains an alanine residue linked to an aminoethylphosphonic acid moiety through a peptide bond.
L-Alanyl-L-1-aminoethylphosphonic acid (CAS 60668-24-8) References
- Alafosfalin as a selective agent for isolation of salmonella from clinical samples. | Perry, JD., et al. 2002. J Clin Microbiol. 40: 3913-6. PMID: 12409351
- Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells. | Neumann, J., et al. 2004. Eur J Biochem. 271: 2012-7. PMID: 15128310
- Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT. | Doki, S., et al. 2013. Proc Natl Acad Sci U S A. 110: 11343-8. PMID: 23798427
- Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance. | Marrs, ECL., et al. 2020. Molecules. 25: PMID: 32210055
- Antibacterial activity of phosphono dipeptides related to alafosfalin. | Lejczak, B., et al. 1986. J Med Chem. 29: 2212-7. PMID: 3783584
- Activity of a peptidyl prodrug, alafosfalin, against anaerobic bacteria. | Grappel, SF., et al. 1985. Antimicrob Agents Chemother. 27: 961-3. PMID: 4026269
- Alafosfalin, a new inhibitor of cell wall biosynthesis: in vitro activity against urinary isolates in Japan and potentiation with beta-lactams. | Maruyama, HB., et al. 1979. Antimicrob Agents Chemother. 16: 444-51. PMID: 518073
- Genetic characterization and molecular cloning of the tripeptide permease (tpp) genes of Salmonella typhimurium. | Gibson, MM., et al. 1984. J Bacteriol. 160: 122-30. PMID: 6090406
- Phosphonopeptides as substrates for peptide transport systems and peptidases of Escherichia coli. | Atherton, FR., et al. 1983. Antimicrob Agents Chemother. 24: 522-8. PMID: 6360039
- Antibacterial activity and mechanism of action of phosphonopeptides based on aminomethylphosphonic acid. | Atherton, FR., et al. 1982. Antimicrob Agents Chemother. 22: 571-8. PMID: 6758686
- The fractional inhibitory concentration (FIC) index as a measure of synergy. | Hall, MJ., et al. 1983. J Antimicrob Chemother. 11: 427-33. PMID: 6874629
- Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships. | Atherton, FR., et al. 1980. Antimicrob Agents Chemother. 18: 897-905. PMID: 7016027
- Penetration of alafosfalin and ampicillin into tissue cage fluid in rabbits. | Henning, C. and Cars, O. 1982. Chemotherapy. 28: 185-8. PMID: 7094659
- In vitro potentiation of cephalosporins by alafosfalin against urinary tract bacteria. | Arisawa, M., et al. 1982. Antimicrob Agents Chemother. 21: 706-10. PMID: 7103452
Activator of:
PEPT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Alanyl-L-1-aminoethylphosphonic acid, 250 mg | sc-257647 | 250 mg | $221.00 |