epitope corresponding to amino acids 161-460 mapping at the C-terminus of Dynactin p62 of human origin
recommended for detection of Dynactin p62 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Dynactin p62 Background Information Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein (1). Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end (2-5). The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1 (2). Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (1). In addition, Dynactin p62 is distributed in the nucleus at very high expression levels (1). Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton (2-4).
Dynactin p62 (H-300)
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Dynactin p62 (H-300): sc-25730. Western blot analysis of Dynactin p62 expression in Sol8 whole cell lysate.
Dynactin p62 (H-300): sc-25730. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and nuclear localization.
Dynactin p62 (H-300): sc-25730. Western blot analysis of Dynactin p62 expression in BC3H1 whole cell lysate.
Dynactin p62 (H-300): sc-25730. Western blot analysis of Dynactin p62 expression in RAW 264.7 whole cell lysate.
