epitope mapping within an internal region of NC2α of human origin
recommended for detection of NC2α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-17272 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-17272 X, 200 µg/0.1 ml
NC2α Background Information NC2 (negative cofactor 2) is a dimeric histone-fold complex that represses RNA polymerase II transcription through binding to TBP and inhibiting the transcription factors TFIIA and TFIIB. NC2 consists of two subunits, termed NC2å and NC2∫, and these subunits dimerize and bind to TBP-promoter complexes via histone fold domains of the H2A-H2B type. NC2 associates with promoters in a manner that correlates with transcriptional activity and with occupancy by basal transcription factors. NC2 binds directly to DNA, and the binding of NC2 to TBP-promoter complexes affects the conformation of DNA, and results in the inhibition of TFIIB.
NC2α (V-18) Références bibliographiques
Consulter les citations pour ces anticorps NC2α (V-18): sc-17272 et/ou un anticorps NC2α (V-18) conjugué.
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NC2α (V-18)
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NC2α (V-18): sc-17272. Western blot analysis of NC2α expression in SK-BR-3 nuclear extract.
