IFI-202 Antibody (F-7): sc-166253
- IFI-202 Antibody (F-7) is a mouse monoclonal IgG1 κ IFI-202 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 316-385 mapping near the C-terminus of IFI-202 of mouse origin
- IFI-202 Antibody (F-7) is recommended for detection of IFI-202a and IFI-202b of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IFI-202 Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IFI-202 Antibody (F-7) for WB and IHC(P) applications. These reagents are now offered in bundles with IFI-202 Antibody (F-7) (see ordering information below).
IFI-202 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects IFI-202 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IFI-202 (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IFI-202 plays a crucial role in immune response regulation, primarily functioning as a nuclear phosphoprotein that inhibits cell growth by modulating transcriptional activity of key regulatory proteins such as NFκB, E2F, AP-1, and p53. This inhibition helps control cellular proliferation and apoptosis, thereby influencing immune response and potentially impacting cancer progression. IFI-202 belongs to a larger family of interferon-inducible proteins, including IFI-203, IFI-204, and D3, all encoded by genes located in the q21-q23 region of chromosome 1. These proteins share homologous segments, highlighting their evolutionary relationship and functional similarities. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have been identified, with MNDA being specifically expressed in granulocyte-macrophage lineage cells and IFI-16 being constitutively expressed in various T and B cell lines, further underscoring IFI-202′s importance in immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFI-202 Antibody (F-7) References:
- The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. | Briggs, RC., et al. 1994. Blood. 83: 2153-62. PMID: 7512843
- IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. | Dawson, MJ. and Trapani, JA. 1995. J Cell Biochem. 57: 39-51. PMID: 7536752
- A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes. | Tannenbaum, CS., et al. 1993. J Leukoc Biol. 53: 563-8. PMID: 7684766
- The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. | Min, W., et al. 1996. Mol Cell Biol. 16: 359-68. PMID: 8524315
- Characterization of the human myeloid cell nuclear differentiation antigen gene promoter. | Kao, WY., et al. 1996. Biochim Biophys Acta. 1308: 201-4. PMID: 8809111
- Inhibition of E2F-mediated transcription by p202. | Choubey, D., et al. 1996. EMBO J. 15: 5668-78. PMID: 8896460
- p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. | Datta, B., et al. 1996. J Biol Chem. 271: 27544-55. PMID: 8910340
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFI-202 Antibody (F-7) | sc-166253 | 200 µg/ml | $322.00 | |||
IFI-202 Antibody (F-7): m-IgG Fc BP-HRP Bundle | sc-528930 | 200 µg Ab; 10 µg BP | $361.00 | |||
IFI-202 Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-521545 | 200 µg Ab, 40 µg BP | $361.00 | |||
IFI-202 Antibody (F-7): m-IgG1 BP-HRP Bundle | sc-543218 | 200 µg Ab; 20 µg BP | $361.00 | |||
IFI-202 Antibody (F-7) AC | sc-166253 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IFI-202 Antibody (F-7) HRP | sc-166253 HRP | 200 µg/ml | $322.00 | |||
IFI-202 Antibody (F-7) FITC | sc-166253 FITC | 200 µg/ml | $336.00 | |||
IFI-202 Antibody (F-7) PE | sc-166253 PE | 200 µg/ml | $349.00 | |||
IFI-202 Antibody (F-7) Alexa Fluor® 488 | sc-166253 AF488 | 200 µg/ml | $364.00 | |||
IFI-202 Antibody (F-7) Alexa Fluor® 546 | sc-166253 AF546 | 200 µg/ml | $364.00 | |||
IFI-202 Antibody (F-7) Alexa Fluor® 594 | sc-166253 AF594 | 200 µg/ml | $364.00 | |||
IFI-202 Antibody (F-7) Alexa Fluor® 647 | sc-166253 AF647 | 200 µg/ml | $364.00 | |||
IFI-202 Antibody (F-7) Alexa Fluor® 680 | sc-166253 AF680 | 200 µg/ml | $364.00 | |||
IFI-202 Antibody (F-7) Alexa Fluor® 790 | sc-166253 AF790 | 200 µg/ml | $364.00 |