santa cruz biotechnology, inc.
goat polyclonal IgG, 200 µg/ml epitope mapping within a cytoplasmic domain of GABAA Rγ1 of human origin recommended for detection of GABAA Rγ1 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with GABAA Rγ2 or GABAA Rγ3 ; also reactive with additional species, including equine blocking peptide, sc-160344 P
Conditions Générales
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Espèce
Nom du Gène
Gene ID
Localisation chromosomique
Numéro d'accession de l'isoforme (ARNm)
Numéro d'accession de la protéine
Numéro OMIM™
Humain
GABRG1
2565
4p12
Q8N1C3
137166
Souris
Gabrg1
14405
5 C3.1
Q9R0Y8
Non disponible
GABAA Rγ1 Background Information GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA functions as the main inhibitory transmitter by increasing a Cl- (chloride) conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class of receptors called GABAC. The © subunit of GABAA receptors are important for benzodiazepine binding and modulation of GABA-mediated Cl- current. GABAA R©1 (gamma-aminobutyric acid (GABA) A receptor, gamma 1), also known as GABRG1, is a 465 amino acid multi-pass membrane protein belonging to the ligand-gated ionic channel (TC 1.A.9) family. GABAA R©1 participates in neurotransmission inhibition and has been linked to alcohol dependence.
GABAA Rγ1 (G-15)
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GABAA Rγ1 (G-15): sc-160344. Western blot analysis of GABAA Rγ1 expression in mouse brain tissue extract.
GABAA Rγ1 (G-15): sc-160344. Western blot analysis of GABAA Rγ1 expression in mouse brain tissue extract.
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