ERK 2 Antibody (33): sc-136288

ERK 2 Antibody (33) is a mouse monoclonal IgG2b antibody raised against amino acids 219-358 of ERK 2 of rat origin, exhibiting strong species reactivity with mouse, rat, human, and canine proteins in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). ERK2 (Extracellular Signal-Regulated Kinase 2), also known as MAPK1 or p42 MAPK, is a pivotal component of the mitogen-activated protein kinase (MAPK) signaling pathways, which are activated by various extracellular stimuli including growth factors, steroid hormones, G protein-coupled receptor ligands, and neurotransmitters. ERK2 is activated through phosphorylation by upstream kinases like MAP kinase kinase (MEK), MEK kinase, and Raf-1 at specific threonine and tyrosine residues within the Thr-Glu-Tyr motif. Upon activation, ERK2 translocates from the cytoplasm to the nucleus, a critical movement that allows ERK2 to phosphorylate nuclear targets such as transcription factors, thereby influencing essential cellular processes like proliferation, differentiation, and development. The nuclear localization of ERK2 is crucial because ERK2 directly affects gene expression and cellular responses to external signals. Anti-ERK 2 antibody (33) is an indispensable tool for researchers investigating the MAPK/ERK signaling pathway and its role in various physiological and pathological conditions.

The preferred p-ERK antibody is p-ERK Antibody (E-4): sc-7383.