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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-12889-R
- recommended for detection of BRCA1 of human origin phosphorylated at Ser 1497 by WB, IP, IF and ELISA
- blocking peptide, sc-12889 P
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Conditions GénéralesRéférences bibliographiques
Accessoires recommandés:
(Cliquez sur l'application voulue)
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| Espèce |
Nom du Gène |
Gene ID |
Localisation chromosomique |
Numéro d'accession de l'isoforme (ARNm) |
Numéro d'accession de la protéine |
Numéro OMIM™ |
| Humain |
BRCA1 |
672 |
17q21.31 |
NM_007294, NM_007295, NM_007296, NM_007297, NM_007298, NM_007299, NM_007300, NM_007302, NM_007303, NM_007304, NM_007305 |
P38398
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113705 |
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BRCA1 Background Information
BRCA1 is a cell cycle-regulated nuclear protein that is phosphorylated mainly on serine and to a lesser extent on threonine residues (1). Changes in phosphorylation occur in response to cell cycle progression and DNA damage (1). BRCA1 undergoes hyperphosphorylation during late G1 and S phases of the cell cycle (1). BRCA1 is a substrate of ATM kinase, and phosphorylation of BRCA1 requires the presence of a functional ATM protein (2,3). Chk2 regulates BRCA1 function after DNA damage by phosphorylating Serine 988 of BRCA1 (4). This phosphorylation is required for the release of BRCA1 from Chk2 and the ability of BRCA1 to restore survival after DNA damage (4). BRCA1 is also phosphorylated at Serine 1497, which is part of a cyclin-dependent kinase consensus site (1).
| p-BRCA1 (Ser 1497) Références bibliographiques |
Consulter les citations pour ces anticorps p-BRCA1 (Ser 1497): sc-12889 et/ou un anticorps p-BRCA1 (Ser 1497) conjugué.
1 total citations En chargeant des citations.
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p-BRCA1 (Ser 1497)
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p-BRCA1 (Ser 1497): sc-12889. Western blot analysis of p-BRCA1 expression in HeLa (A) and UV-irradiated HeLa (B) whole cell lysates.
p-BRCA1 (Ser 1497): sc-12889. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
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