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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of MAGE-A1 of human origin
- recommended for detection of a broad range of MAGE family members of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, bovine and porcine
- blocking peptide, sc-12805 P
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Conditions Générales
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MAGE Background Information
The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types, but not in normal tissues, with the exception of testis and placenta. Although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their function in normal cells remains unknown. |
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MAGE (Y-18)
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MAGE (Y-18): sc-12805. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse testis tissue showing cytoplasmic and membrane localization.
MAGE (Y-18): sc-12805. Western blot analysis of MAGE-A12 expression in non-transfected: sc-110760 (A) and human MAGE-A12 transfected: sc-110824 (B) 293 whole cell lysates. |
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