α2B-AR Background Information å2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include three highly homologous subtypes: å2A, å2B, and å2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. åB-adrenergic receptors (a2B-AR) couple to Gi-protein and induce salt-dependent hypertension in response to catecho-lamines. The carboxy-terminal cytoplasmic domain of a2B-AR can associate with proteins, including the guanine nucleotide exchange factor eIF-2B. å2B-AR transcripts are abundant in rat liver and kidney.
α2B-AR (H-96) Références bibliographiques
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α2B-AR (H-96)
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α2B-AR (H-96): sc-10723. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.
α2B-AR (H-96): sc-10723. Western blot analysis of α2B-AR expression in Hep G2 whole cell lysate.
