SAP 30BP Background Information
SAP 30BP (SAP 30 binding protein), also known as HTRG, HTRP or HCNGP, is a 308 amino acid protein that belongs to the HCNGP family and is believed to function as a transcription regulator. Expressed in brain, liver, spleen, kidney, lung and heart, SAP 30BP localizes to the nucleus and is induced in fibroblasts by binding of HSV-1 (herpes simplex virus 1). In the nucleus, SAP 30BP interacts with SAP 30, a component of the histone deacetylase complex that also contains mSin3A, HDAC1, HDAC2, RbAp48, RbAp46 and SAP 18. Via this interaction, SAP 30BP is thought to play a role in the regulation of genes related to cell survival. In addition, SAP 30BP is capable of inducing cell death, suggesting that it functions in cellular corepression of transcription and inhibition of cell survival.
