epitope corresponding to phosphorylated Ser 518 of NF2 of human origin
recommended for detection of Ser 518 phosphorylated NF2 of human and mouse origin and correspondingly phosphorylated Ser 514 of rat origin by WB and IP
p-NF2 Background Information Neurofibromatosis type 2 (NF2) is a dominantly inherited disorder characterized by the occurance of bilateral vestibular schwannomas and other central nervous system tumors, including multiple meningiomas. NF2 occurs in about 1 of 40,000 live births. The NF2 gene is highly penetrant; NF2-affected individuals have a 95% chance of developing bilateral vestibular schwannomas. NF2 is distinct from NF1, which is characterized by an incidence of 1 in 4000, maps to chromosome 17 and encodes a protein designated neurofibromin, which is a large protein with a GAP domain. Genetic linkage studies of both sporadic and familial tumors suggest that NF2 is caused by inactivation of a tumor suppressor gene that maps on chromosome 22q12 and encodes a 595 amino acid protein whose function appears to be mediated by interaction with the cytoskeleton.
p-NF2 (Ser 518)
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p-NF2 (Ser 518): sc-101735. Western blot analysis of phosphorylated NF2 expression in untreated (A) and IFN-α-treated (B) HUVEC whole cell lysates.
p-NF2 (Ser 518): sc-101735. Western blot analysis of NF2 phosphorylation in non-transfected: sc-117752 (A) and human NF2 transfected: sc-172383 (B) 293T whole cell lysates.
