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- rabbit polyclonal IgG, 100 µg/ml
- epitope corresponding to phosphorylated Ser 65 of BimEL/L of human origin
- recommended for detection of Ser 65 phosphorylated BimEL/L of mouse and rat origin and correspondingly phosphorylated Ser 69 of human origin by IF and IHC(P)
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Conditions GénéralesRéférences bibliographiques
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p-BimEL/L Background Information
Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins, and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS and BimL, implying a unique role for BimEL in cell survival signaling.
| p-BimEL/L (Ser 65) Références bibliographiques |
Consulter les citations pour ces anticorps p-BimEL/L (Ser 65): sc-101646 et/ou un anticorps p-BimEL/L (Ser 65) conjugué.
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p-BimEL/L (Ser 65)
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p-BimEL/L (Ser 65): sc-101646. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytolasmic staining.
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