MRP-L12 Antibody (397.1): sc-100839

MRP-L12 Antibody (397.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP-L12 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MRP-L12 Antibody (397.1) is available as the non-conjugated anti-MRP-L12 antibody (397.1). MRP-L12 protein, also known as mitochondrial ribosomal protein L12, plays a crucial role in mitochondrial protein synthesis, which is essential for maintaining cellular energy production and overall cellular function. Located within the mitochondria, MRP-L12 is vital for the assembly of the mitochondrial ribosome, where MRP-L12 contributes to the translation of mitochondrial mRNAs. This process is particularly important because mitochondria are responsible for generating ATP through oxidative phosphorylation, and any impairment in MRP-L12 can lead to reduced cell growth rates and decreased ATP production. Notably, MRP-L12 is cleaved during translocation across the mitochondrial membrane and forms dimers that associate with the large ribosomal subunit, highlighting MRP-L12′s structural significance in ribosome assembly. With a length of 198 amino acids, MRP-L12 belongs to the ribosomal protein L12P family and is highly expressed in the colon, indicating MRP-L12′s potential involvement in tissue-specific mitochondrial functions.

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MRP-L12 Antibody (397.1) References:

1. The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.  |  Frei, C., et al. 2005. EMBO J. 24: 623-34. PMID: 15692573
2. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.  |  Wang, Z., et al. 2007. J Biol Chem. 282: 12610-8. PMID: 17337445
3. A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein.  |  Marty, L. and Fort, P. 1996. J Biol Chem. 271: 11468-76. PMID: 8626705
4. Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12.  |  Marty, L., et al. 1997. Genomics. 41: 453-7. PMID: 9169145
5. Characterization of the human mitochondrial ribosomal S12 gene.  |  Johnson, DF., et al. 1998. Genomics. 52: 363-8. PMID: 9790755

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MRP-L12 Antibody (397.1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MRP-L12 Antibody (397.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MRP-L12 Antibody (397.1) Specifications

Alternate Product Name: MRP-L12

Product Clone Name: 397.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-199

Epitope Target: MRP-L12

Epitope Species: human

Product Reactivity/Detection: MRP-L12

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MRP-L12 Antibody (397.1): N/A