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GRF Anticuerpos

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un sistema único para la rápida identificación de GRF Anticuerpos. Desplace el puntero sobre los nombres de los productos de la tabla para ver los datos representativos de cada producto.

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NOMBRE DEL PRODUCTO NÚMERO DEL CATÁLOGO:ISOTIPOEPíTOPOAPLICACIONESESPECIESMENCIONESCLASIFICACIÓN
GRF-1 (N-13)sc-131536cabra IgGN-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
GRF-1 (C-14)sc-131534cabra IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b, p
GRF-1 (2389D3a)sc-81094ratón IgG1Internal (h)WB, IPhumano

GRF silenciadores génicos siARN, Plásmidos de shARN y Partículas Lentivirales shRNA incluyendo:

siRNAsPlásmidos shRNAshRNA partículas antiviralesMENCIONESCLASIFICACIÓN
GRF-1 siRNA (m): sc-41706GRF-1 shRNA Plasmid (m):
sc-41706-SH		GRF-1 shRNA (m)
Partículas Lentiviral  :sc-41706-V
GRF-1 siRNA (h): sc-97682GRF-1 shRNA Plasmid (h):
sc-97682-SH		GRF-1 shRNA (h)
Partículas Lentiviral  :sc-97682-V

The glucocorticoid receptor (GR) is a ligand-dependent, transactivating regulatory protein that is a member of the nuclear receptor superfamily. GRF-1 (glucocorticoid receptor DNA-binding factor 1), also known as p190RhoGAP or simply p190, is a transcriptional regulator which binds to the promoter region of the glucocorticoid receptor gene and represses its expression. By repressing GR expression, GRF-1 acts to down-regulate Rho signaling, thereby mediating both actin cytoskeletal rearrangements and cell cycle events. Through its GAP domain, GRF-1 is thought to affect cytokinesis by regulating Rho activity; a regulation that is controlled by the ubiquination of the GTP binding region and subsequent degradation of GRF-1. Additionally, GRF-1 plays an important role in oligodendrocyte differentiation, a process that is absent in malignant glioma tumors, implicating GRF-1 as a possible tumor suppressor. GRF-1 expression is regulated by glucocorticoids and the expressed protein exists as two isoforms produced by alternative splicing events.