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  Phosphatases and Phosphatase Activators and Inhibitors
PRODUCTOCATALOG #DESCRIPTIONAMOUNT
1,4-Dimethylendothall
sc-201327
A structural analog of endothall, which shows no inhibition of PP2A activity. Useful negative control for endothall and cantharidin.
10 mg/50 mg
3,4-Dephostatin
sc-220885
A protein tyrosine phosphatase inhibitor that enhances growth factor-induced differentiation in PC12 cells possibly by sustaining MAP kinase activity. Can also be used as a protein S-nitrosylating agent and exhibits greater stability than Dephostatin.
1 mg
4-Aminophenylphosphate sodium salt
sc-220931
A substrate for the electrochemical measurement of alkaline phosphatase.
10 mg
5-Bromo-6-chloro-3-indolyl phosphate, p-toluidine salt
sc-221017
A histochemical substance used to visualize alkaline phosphatase activity. Hydrolysis of the phosphate group by alkaline phosphatase generates an insoluble indigo compound.
100 mg/250 mg
α-Naphthyl Acid Phosphate, Monosodium Salt
sc-202898
Reported to be an alkaline, acid, and protein phosphatase inhibitor. Also been shown to dephosphorylate the actin-depolymerizing protein, Cofilin 1, in platelets.
5 g
Artesunate
sc-201329
A derivative of artemisinin with anti-microbial properties
10 mg/50 mg
Benzylphosphonic Acid
sc-200588
A protein tyrosine phosphatase (PTP) inhibitor that also inhibits COX-1 and COX-2.
100 mg/500 mg
Benzylphosphonic Acid-(AM)2
sc-221349
A bis-acetoxymethyl ester (AM) derivative of benzylphosphonic acid which is cell permeable and is converted to the active phosphonic acid via intracellular esterase-catalyzed cleavage of the AM esters.
10 mg/50 mg
Beryllium fluoride
sc-263025
Project-Id-Version: Report-Msgid-Bugs-To: POT-Creation-Date: 2013-05-13 21:34-0800 PO-Revision-Date: Last-Translator: M Language-Team: Language: es_US MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit X-Poedit-Basepath: /Library/WebServer/Documents/ X-Poedit-SourceCharset: UTF-8 X-Poedit-Bookmarks: -1,-1,719,-1,-1,-1,-1,-1,-1,-1 X-Generator: Poedit 1.5.3 X-Poedit-SearchPath-0: www.scbt.com
5 g
β-Glycerophosphate, Disodium Salt, Pentahydrate
sc-203323
A simple phosphate donor, acts as an inhibitor to phosphatase and as a source of phosphate for biological studies.
50 g/100 g
bpV(bipy)
sc-221376
This is a protein phosphotyrosine phosphatase inhibitor.
5 mg/25 mg
bpV(HOpic)
sc-221377
This is a protein phosphotyrosine phosphatase inhibitor.
5 mg
bpV(phen)
sc-221378
A peroxovanadium insulin mimetic compound. Inhibits the dephosphorylation of insulin receptors by blocking protein phosphotyrosine phosphatase activity.
5 mg/25 mg
bpV(pic)
sc-221379
A vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic.
5 mg/25 mg
Caged Ins(1,4,5)P3, Trisodium Salt
sc-221392
A photo-activated derivative of Ins(1,4,5)P3. It is not biologically active or metabolized by endogenous phosphatase.
10 µg
Calyculin A
sc-24000
Shown to increase the degree of phosphorylation of Histone H3, PRK2 and beta-catenin; while also acting as a potent, cell permeable, inhibitor of protein phosphatase 1(EC50), 2A and the endogenous phosphatase of smooth muscle myosin B; EC50 = 8nM, 0.3 nM and 0.7 nM respectively.
10 µg/100 µg
Cantharidic Acid
sc-201323
An analog of cantharidin (CA) that is a potent and selective inhibitor of protein phosphatase (PP2A) and protein phosphatase 1 (PP1). Does not inhibit PP2B or PP2C.
10 mg/50 mg
Cantharidin
sc-201321
A small molecule herbicide and potent inhibitor of PP2A (IC50=40 nM).
25 mg/100 mg
Ceramide C6
sc-3527
Ceramide C6 has shown to activate MAP kinase and PP2A along with apoptosis of Molt-4 and HL-60, enhance COX-2 in rats and aortic smooth muscle in bovines, suppress Tyr Phospohorylation and inhibit glycoprotein traffic.
5 mg/25 mg
CinnGEL 2Me
sc-205633
CinnGEL 2Me is a cell permeable protein tyrosine phosphatase-1B (PTP1B) inhibitor.
1 mg
Cypermethrin
sc-24012
A potent inhibitor of calcineurin (protein phosphatase 2B).
10 mg/50 mg
Deltamethrin
sc-24013
A Type II pyrethroid insecticide that potently inhibits calcineurin with an IC50 of 10-9 to 10-11 M.
10 mg/50 mg
Dephostatin
sc-202131
PTP inhibitor. Competitively inhibits PTP activity in membrane preparations from human neoplastic T cell line. Reported to mobilize intracellular calcium. Stable NO donor for S-nitrosylation of proteins
1 mg
eIF-2α Inhibitor II, Sal003
sc-221582
A potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal (sc-202332), with enhanced aqueous solubility, that has been shown to prevent the dephosphorylation of eIF-2α.
5 mg
Endothall
sc-201325
A small molecule herbicide and inhibitor of PP2A (IC50=970 nM).
20 mg/100 mg
Ethyl-3,4-Dephostatin
sc-220886
A more stable ethyl analog of 3,4-Dephostatin. Potently inhibits protein tyrosine phosphatase 1B.
1 mg
Fenvalerate
sc-24014
A type II pyrethoid. Potent inhibitor of calcineurin, suggested activity at GABA receptors as benzodiazepine agonists, and other potential synaptic and neuronal activity.
25 mg/100 mg
L-p-Bromotetramisole Oxalate
sc-201431
An inhibitor of non-specific alkaline phosphatase. Also shows inhibition of tyrosine phosphatases.
5 mg/50 mg
Lambda Phosphatase
sc-200312
Releases phosphate groups from phosphorylated serine, threonine and tyrosine residues in proteins; also active on phosphorylated histidine residues
0.25 ml/0.05 ml
MBCQ
sc-221874
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM).
5 mg/25 mg
mpV(pic)
sc-221958
A protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator.
10 mg
Okadaic Acid
sc-3513
Potent and selective inhibitor of PP1 and PP2A phosphatases; reduces outgrowth of PC12 cells.
25 µg/100 µg
Okadaic Acid Sodium Salt
sc-202259
A dinoflagellate toxin and potent inhibitor of PP1A and PP2A/B. A known tumor promoter.
25 µg/100 µg
Okadaic Acid, Ammonium Salt
sc-202260
Shown to be a protein phosphatase regulator via non-competitive or mixed inhibition of the okadaic acid-sensitive enzymes. Also reported to induce ornithine decarboxylase in mouse skin
25 µg
p-Nitrophenyl Phosphate 50X solution
sc-358718
50X liquid alkaline phosphatase substrate used in E applications; absorbs light at 405nm.
10 ml
Permethrin
sc-201319
A common pesticide. Causes prolonged activation of Na+ channels disturbing neuronal function.
10 mg/50 mg
PRL-3 Inhibitor
sc-222189
A cell-permeable benzylidene rhodanine compound that potently inhibits hPRL-3, a member of the regenerating liver family tyrosine phosphatases. Shown to reduce the invasiveness of murine melanoma B16F10 cells.
10 mg
PTP CD45 Inhibitor
sc-222223
A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45. Does not effectively inhibit PTPIB and the phenanthrenedione group does not function as a thiol oxidizing agent.
1 mg
PTP Inhibitor I
sc-204220
A potent covalent inhibitor of protein tyrosine phosphatases SHP-1 and PTPIB.
10 mg/100 mg
PTP Inhibitor II
sc-202784
A cell-permeable, covalent and potent protein tyrosine phosphatase (PTP) inhibitor.
25 mg
PTP Inhibitor III
sc-222224
A cell-permeable compound that inhibits a broad-range of protein tyrosine phosphatases (PTPs).
10 mg
PTP Inhibitor IV
sc-222225
An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases.
10 mg
PTP1B Inhibitor
sc-222227
An inhibitor that blocks the activity of enzyme PTP1B, a key factor in the negative regulation of insulin and leptin signaling pathway.
5 mg
Resmethrin
sc-202312
Has been reported to be a potent inhibitor of the neural calcium-calmodulin-dependent protein phosphatase, calcineurin. Also shown to eliminate constitutive nitric oxide release from lobster heart.
10 mg/25 mg
RK-682
sc-202319
An inhibitor of protein tyrosine phosphatase, blocking dephosphorylation of CD45 and VHR. Inhibitor of heparanase activity.
200 µg/1 mg
RK-682, Streptomyces sp.
sc-202791
An effective tyrosine phosphatase inhibitor that does not permeate the cell membrane.
200 µg
RWJ-60475
sc-222266
RWJ-60475 is an inhibitor of the CD45 tyrosine phosphatase (IC50=2 µM). It is not cell permeable. It is a hydrolytically stable bioisostere of phosphotyrosine which binds to the CD45 catalytic site.
5 mg/25 mg
RWJ-60475-(AM)3
sc-222267
A cell-permeable acetoxymethyl (AM) ester of RWJ-60475. The AM esters promote cell membrane permeability and are hydrolyzed by intracellular esterases which traps the active inhibitor within the cell.
1 mg
Salubrinal
sc-202332
Cell permeable and selective inhibitor of eIF-2α, shown to protect cells from ER stress-induced apoptosis induced by tunicamycin (sc-201539), and brefeldin A (sc-200861).
1 mg/5 mg
Sodium Fluoride
sc-24988
Sodium Fluoride (NaF) is an inhibitor of serine/threonine phosphatases. Also an activator of G proteins. NaF is widely studied in bone and dental research.
125 g/5 g/500 g
Sodium Stibogluconate
sc-202815
A robust inhibitor of PTPases, including PTPase1 (SHP-1), SHP-2, and PTP1B. Also augments cytokine response and forms a complex with PTPase.
1 g
Tautomycin
sc-200587
Potent and selective protein phosphatase inhibitor that functions as an antifungal antibiotic. Shows greater inhibition for PP1 versus PP2, and can activate the Raf-1 pathway.
25 µg
Ursodeoxycholic Acid, Sodium Salt
sc-222407
This reduces hydrophobic bile acids as well as decreases lymphocyte reactivity and serum alkaline phosphatase levels when used in the treatment for primary biliary cirrhosis. I interferes with ileal absorption of toxic endogenous bile acids.
1 g