sc-222326

This is a cell-permeable naphthyridinyl-phenolic compound which selectively enhances cytokine-induced STAT1 transcription activity, but not STAT3 or NF-˚B transcription activity. It is shown to prolong INF-g-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.

25 mg

sc-200615

A potential anti-inflammatory agent, thought to act through the irreversible inhibition of cytokine-inducible IBα phosphorylation, leading to the inactivation of NF-κB

10 mg/50 mg/5 mg

sc-200800

Derived from propolis, and shown to have anti-carcinogenic, anti-inflammatory, and immunomodulatory properties; as well as potent NF-κB inhibition.

20 mg/100 mg

sc-205930

Shows anti-inflammatory, immunomodulatory and anti-carcinogenic properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), cyclooxygenase-2 (COX-2)and prostaglandin E2 (PGE2). Prevents DNA single-strand breaks caused by H₂O₂.

50 mg/250 mg

sc-222061

An inhibitor of NF-κB transcriptional activity, does not affect IκB degradation.

5 mg/50 mg

sc-203216

Project-Id-Version: Report-Msgid-Bugs-To: POT-Creation-Date: 2013-05-13 21:34-0800 PO-Revision-Date: Last-Translator: M Language-Team: Language: es_US MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit X-Poedit-Basepath: /Library/WebServer/Documents/ X-Poedit-SourceCharset: UTF-8 X-Poedit-Bookmarks: -1,-1,719,-1,-1,-1,-1,-1,-1,-1 X-Generator: Poedit 1.5.3 X-Poedit-SearchPath-0: www.scbt.com

10 mg

sc-351846

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 µM versus 0.89 µM (ChTL); 34.4 µM versus 104.43 µM (TL); 2.95 µM versus 5.70 µM (PGPH), respectively).

1 mg/5 mg

sc-3520

A metabolite of acetylsalicylic acid (sc-217570), functions by inhibiting NF-κB and reducing oxidative stress.

1 g/25 g