CASC3 Anticuerpo(H-190): sc-98359

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CASC3 (cancer susceptibility candidate 3), also known as BTZ or MLN51, is a 703 amino acid protein that localizes to both the nucleus and the cytoplasm and contains a coiled coil domain. Expressed in a variety of tissues, CASC3 functions as a component of the exon junction complex (EJC), a multi-protein structure that exists on spliced mRNAs and plays a role in nonsense-mediated mRNA decay at exon-exon junctions. As a component of the EJC, CASC3 is thought to participate in mRNA modification and may also be involved in mRNA transport and ribonucleoprotein particle function. CASC3 is overexpressed in breast and gastric cancers, suggesting a role for CASC3 in tumor development and metastasis. The gene encoding CASC3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.