NELF-D Anticuerpo(N-16): sc-85779

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NELF-D (negative elongation factor C/D), also known as TH1, NELF-C, HSPC130 or TH1L, is a 590 amino acid protein that localizes to the nucleus and exists as a component of the multi-protein NELF complex, a structure which negatively regulates Pol II-dependent transcription elongation. Expressed in a variety of tissues, including liver, heart, kidney, lung, brain, placenta and pancreas, NELF-D is involved in controlling transcriptional pausing of Pol II and may be able to induce chromatin unfolding, possibly playing a role in tumorigenesis. NELF-D is encoded by a gene which maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.