ZBED1 Background Information ZBED1 (zinc finger BED domain-containing protein 1), also known as ALTE (Ac-like transposable element), DREF or TRAMP, is a 694 amino acid protein that localizes specifically to granular structures within the nucleus. Expressed ubiquitously at low levels and present at higher levels in heart, placenta, spleen and skeletal muscle, ZBED1 is thought to function as a transcription factor that regulates a number of ribosomal protein (RP) encoding genes, thereby playing a role in the cell cycle and in cell proliferation events. ZBED1 contains one BED-type zinc finger and binds specifically to 5'-TGTCG[CT]GA[CT]A-3' DNA regions found in RP promotors. Additionally, ZBED1 binds strongly to the promotor region of Histone H1 (a protein required for the condensation of nucleosomes into higher order structures), subsequently activating H1 transcription.
ZBED1 (41-R)
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ZBED1 (41-R): sc-81823. Western blot analysis of ZBED1 expression in non-transfected: sc-117752 (A) and human ZBED1 transfected: sc-111867 (B) 293T whole cell lysates.
ZBED1 (41-R): sc-81823. Western blot analysis of ZBED1 expression in HeLa nuclear extract.
ZBED1 (41-R): sc-81823. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
ZBED1 (41-R): sc-81823. Western blot analysis of ZBED1 expression in non-transfected: sc-117752 (A) and human ZBED1 transfected: sc-172080 (B) 293T whole cell lysates.
