δ-catenin Antibody (40.1): sc-81793

δ-catenin Antibody (40.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects delta-catenin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-delta-catenin antibody (40.1) is available as a non-conjugated format. Delta-catenin, a member of the catenin family, plays a crucial role in regulating cell adhesion and signaling pathways, particularly in the brain where delta-catenin interacts with presenilin 1, a protein implicated in Alzheimer′s disease. Delta-catenin presence in the central nervous system highlights delta-catenin′s importance in neuronal development and synaptic function. Notably, the gene encoding delta-catenin is located on human chromosome 5p15.2, and a hemizygous loss of this gene is associated with Cri-du-Chat syndrome, a genetic disorder characterized by developmental delays and intellectual disability. Delta-catenin interaction with other catenins, such as α-catenin and β-catenin, further emphasizes delta-catenin′s role in maintaining cellular integrity and communication. Additionally, the transmembrane phosphatase PTPm, which associates with catenin/cadherin complexes, may modulate signaling pathways critical for cellular responses.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

δ-catenin Antibody (40.1) References:

1. Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome.  |  Medina, M., et al. 2000. Genomics. 63: 157-64. PMID: 10673328
2. Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1.  |  Zang, X., et al. 2022. Mol Cancer. 21: 141. PMID: 35780119
3. δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.  |  Tan, CX., et al. 2023. J Cell Biol. 222: PMID: 37707499
4. Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.  |  Pierceall, WE., et al. 1995. Oncogene. 11: 1319-26. PMID: 7478552
5. Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells.  |  Breen, E., et al. 1995. Ann Surg Oncol. 2: 378-85. PMID: 7496831
6. Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.  |  Brady-Kalnay, SM., et al. 1995. J Cell Biol. 130: 977-86. PMID: 7642713
7. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.  |  Sacco, PA., et al. 1995. J Biol Chem. 270: 20201-6. PMID: 7650039
8. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.  |  Knudsen, KA., et al. 1995. J Cell Biol. 130: 67-77. PMID: 7790378
9. Beta-catenin expression in human cancers.  |  Takayama, T., et al. 1996. Am J Pathol. 148: 39-46. PMID: 8546224
10. Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat.  |  Ozawa, M., et al. 1995. J Biochem. 118: 836-40. PMID: 8576101
11. Presenilin 1 interaction in the brain with a novel member of the Armadillo family.  |  Zhou, J., et al. 1997. Neuroreport. 8: 2085-90. PMID: 9223106
12. delta-catenin, an adhesive junction-associated protein which promotes cell scattering.  |  Lu, Q., et al. 1999. J Cell Biol. 144: 519-32. PMID: 9971746

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-δ-catenin Antibody (40.1) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-δ-catenin Antibody (40.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

δ-catenin Antibody (40.1) Specifications

Alternate Product Name: δ-catenin

Product Clone Name: 40.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1081-1191

Epitope Target: δ-catenin

Epitope Species: human

Product Reactivity/Detection: δ-catenin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for δ-catenin Antibody (40.1): N/A