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- mouse monoclonal IgG1; 200 µg/ml
- raised against amino acids 680-781 mapping at the C-terminus of β-catenin of human origin
- recommended for detection of β-catenin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
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Información sobre pedidosCitaciones de productos
Productos Recomendados para Ayudar:
(Haga clic en el botón para el applicación de su selección)
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| Especie |
Nombre del Gen |
Identificacion del Gen |
Ubicacion del cromosoma |
Numero de Accesion de Isoforma (ARNm) |
Numero de Accesion de la Proteina |
Número de pedido: |
| Humano |
CTNNB1 |
1499 |
3p22.1 |
NM_001904 |
P35222
|
155255 |
| Ratón |
Ctnnb1 |
12387 |
9 F4 |
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Q02248
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No Aplicable |
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β-catenin Background Information
The catenins, å, ∫ and ©, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. å-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. ∫-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. ∫-catenin has also been found in complexes with the tumor suppressor protein APC (5). ©-catenin, also known as plakoglobin, binds with å-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPµ associates with catenin/cadherin complexes and may regulate complex signaling.
| β-catenin (E-5) Citaciones de productos |
Vea como otros han usado anticuerpos β-catenin (E-5): sc-7963 y/o conjugaciones de anticuerpos β-catenin (E-5)
92 total citations Loading citations.
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β-catenin (E-5)
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β-catenin (E-5): sc-7963. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver carcinoma tissue showing membrane staining (A). Rhodamine immunofluorescence staining of methanol-fixed A-431 cells showing membrane localization of β-catenin and DAPI nuclear counterstain (B).
β-catenin (E-5): sc-7963. Western blot analysis of β-catenin expression in HeLa whole cell lysate.
ChIP analysis of transcription regulatory proteins associated with the Pitx2 promoter in aT3-1 cells in response to lithium. Antibodies tested include LEF-1 (C-19): sc-8592 amd LEF-1 (N-17): sc-8591 (B), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (C), HDAC1 (H-11): sc-7872, HDAC1 (C-19): sc-6298 and HDAC1 (H-11): sc-8410 (D), HDAC2 (C-8): sc-9959, HDAC2 (H-54): sc-7899 and HDAC2 (C-19): sc-6296 (E). Input control (A). Data kindly provided by M.G. Rosenfeld and reproduced with permission from Kioussi et al., Cell 2002, 111: 673-685.
ChIP analysis of coactivator recruitment on Cyclin D2 promoter in C2C12 cells treated with LiCl and serum. Antibodies tested include β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496, β-catenin (E-5): sc-7963, Tip60 (N-17): sc-5725, TRRAP (T-17): sc-5405, TRRAP (Y-18): sc-12375, TRRAP (F-20): sc-12376, TRRAP (H-300): sc-11411, CBP (A-22): sc-369, CBP (C-20): sc-583, CBP (451): sc-1211, CPB (C-1): sc-7300, p300 (H-272): sc-8981, p300 (N-15): sc-584 and p300 (C-20): sc-585. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Kioussi et al., Cell 2002, 111: 673-685.
ChIP analysis of c-Myc promoter occupancy in response to lithium stimulation in serum synchronized C2C12 cells. Antibodies tested include HDAC1 (H-15): sc-7872, HDAC1 (C-19): sc-6298 and HDAC1 (H-11): sc-8410 (A), β-catenin (H-120): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (B), E2F-4 (A-20): sc-1082, E2F-4 (D-3): sc-6851, E2F-4 (RK-13): sc-511 and E2F-4 (C-20): sc-866 (C), and p130 (C-20): sc-317, p130 (211.6): sc-9963 and p130 (H-125): sc-20678 (D). Data kindly provided by M.G. Rosenfeld and reproduced with permission from Proc. Natl. Acad. Sci. 100: 3245-3250. Copyright 2003 National Academy of Sciences, USA.
ChIP analysis of in vivo binding of RORα and its recruitment of coactivators to RORα-responsive promoters in freshly dissected cerebella derived from wild type (+/+) and staggerer (Sg) mice. Control Input (A). Antibodies used included TRβ1 (J51): sc-737 and TRβ1 (J52): sc-738 (B), p300 (C-20): sc-585, p300 (H-272): sc-8981 and p300 (N-15): sc-584 (C), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (D). Data kindly provided by M.G. Rosenfeld and reproduced wtih permission from Gold et al., Neuron 2003, 40: 1119-1131.
ChIP analysis of in vivo binding of RORα and its recruitment of coactivators to RORα-responsive promoters in freshly dissected cerebella derived from wild type (+/+) and staggerer (Sg) mice. Control Input (A). Antibodies used included TRβ1 (J51): sc-737 and TRβ1 (J52): sc-738 (B), p300 (C-20): sc-585, p300 (H-272): sc-8981 and p300 (N-15): sc-584 (C), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (D). Data kindly provided by M.G. Rosenfeld and reproduced wtih permission from Gold et al., Neuron 2003, 40: 1119-1131.
ChIP analysis of in vivo binding of RORα and its recruitment of coactivators to RORα-responsive promoters in freshly dissected cerebella derived from wild type (+/+) and staggerer (Sg) mice. Control Input (A). Antibodies used included TRβ1 (J51): sc-737 and TRβ1 (J52): sc-738 (B), p300 (C-20): sc-585, p300 (H-272): sc-8981 and p300 (N-15): sc-584 (C), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (D). Data kindly provided by M.G. Rosenfeld and reproduced wtih permission from Gold et al., Neuron 2003, 40: 1119-1131.
ChIP analysis of in vivo binding of RORα and its recruitment of coactivators to RORα-responsive promoters in freshly dissected cerebella derived from wild type (+/+) and staggerer (Sg) mice. Control Input (A). Antibodies used included TRβ1 (J51): sc-737 and TRβ1 (J52): sc-738 (B), p300 (C-20): sc-585, p300 (H-272): sc-8981 and p300 (N-15): sc-584 (C), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (D). Data kindly provided by M.G. Rosenfeld and reproduced wtih permission from Gold et al., Neuron 2003, 40: 1119-1131. β-catenin siRNA (h): sc-29209. Western blot analysis of β-catenin expression in non-transfected control (A) and β-catenin siRNA transfected (B) HeLa cells. Blot probed with β-catenin (E-5): sc-7963. α-actinin (H-2): sc-17829 used as specificity and loading control. β-catenin (E-5): sc-7963. Western blot analysis of β-catenin expression in non-transfected: sc-117752 (A) and human β-catenin transfected: sc-116622 (B) 293T whole cell lysates. β-catenin (E-5): sc-7963. Western blot analysis of β-catenin expression in non-transfected: sc-117752 (A) and human β-catenin transfected: sc-116622 (B) 293T whole cell lysates. β-catenin (E-5): sc-7963. Western blot analysis of β-catenin expression in SH-SY5Y whole cell lysate.
β-catenin (E-5): sc-7963. Rhodamine immunofluorescence staining of methanol-fixed A-431 cells showing membrane localization
β-catenin (E-5): sc-7963. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing membrane staining of glandular cells.
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