RARγ/Retinoic Acid Receptor γ Antibody (G-1): sc-7387

RARγ Antibody (G-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects RARγ in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. RARγ monoclonal antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. RARγ, a member of the retinoic acid receptor family, plays a crucial role in regulating gene expression during vertebrate development and tissue differentiation by acting as a nuclear transcription factor. RARγ binding to retinoic acid, a metabolite of vitamin A, is essential for function, as this binding induces conformational changes that facilitate receptor interaction with DNA, thereby promoting transcription of target genes. RARγ is expressed in a tissue-specific manner, with significant roles in skin and lung tissues, where expression can be altered in pathological conditions such as lung cancer. The human RARγ gene is located on chromosome 12q13, and understanding RARγ function and regulation is vital for elucidating the mechanisms of retinoid signaling in health and disease.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RARγ/Retinoic Acid Receptor γ Antibody (G-1) References:

1. The molecular biology of retinoic acid receptors: orphan from good family seeks home.  |  Rees, J. 1992. Br J Dermatol. 126: 97-104. PMID: 1311193
2. Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.  |  Mattei, MG., et al. 1991. Genomics. 10: 1061-9. PMID: 1655630
3. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily.  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
4. Antagonizing RARγ Drives Necroptosis of Cancer Stem Cells.  |  Brown, G. 2022. Int J Mol Sci. 23: PMID: 35563205
5. RARγ: The Bone of Contention for Endothelial Cells in Prostate Cancer Metastasis.  |  Bhowmick, S. and Bhowmick, NA. 2022. Cancer Res. 82: 2975-2976. PMID: 36052494
6. RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.  |  Zhang, FX., et al. 2023. Int Immunopharmacol. 125: 111129. PMID: 37897947
7. Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling.  |  Li, XM., et al. 2024. Cell Rep. 43: 113688. PMID: 38245869
8. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
9. Current use and future potential role of retinoids in dermatology.  |  Orfanos, CE., et al. 1997. Drugs. 53: 358-88. PMID: 9074840
10. [Genetic control of the development by retinoic acid].  |  Mark, M., et al. 1997. C R Seances Soc Biol Fil. 191: 77-90. PMID: 9181129
11. Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers.  |  Lotan, R. 1997. Environ Health Perspect. 105 Suppl 4: 985-8. PMID: 9255592
12. Retinoids and chemoprevention of aerodigestive tract cancers.  |  Lotan, R. 1997. Cancer Metastasis Rev. 16: 349-56. PMID: 9433644

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RARγ/Retinoic Acid Receptor γ Antibody (G-1) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-RARγ/Retinoic Acid Receptor γ Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RARγ/Retinoic Acid Receptor γ Antibody (G-1) Specifications

Alternate Product Name: RARγ

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-454

Epitope Target: RARγ

Epitope Species: human

Product Reactivity/Detection: RARγ1 and RARγ2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for RARγ/Retinoic Acid Receptor γ Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred RARγ/Retinoic Acid Receptor γ antibody is RARγ/Retinoic Acid Receptor γ Antibody (H-6): sc-398065.