Properdin Anticuerpo(K-18): sc-67794

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The serum complement system (SCS), containing over 30 glycoproteins, influences physiological mechanisms of the body in response to immune complex (the classical pathway), carbohydrate (the lectin pathway) or bacterial (alternative pathway) initiation. Properdin, also known as complement factor P (CFP), PFC, BFP or PFD, is a secreted glycoprotein that participates in positively regulating the alternative pathway of the SCS. Properdin exists as a cyclic polymer with six Thrombospondin type-1 domains and binds to C3 and C5 convertase complexes (C3bBb and (C3b)nBb) functioning to assist in their stabilization. Properdin is also required for the deposition of C3b onto the surface of pathogens. Mutations in the gene encoding Properdin can result in Properdin deficiency (PFD), a disease characterized by higher susceptibility to bacterial infections.