NY-ESO-1 Background Information NY-ESO-1, also known as autoimmunogenic cancer/testis antigen, is a tumor-specific shared antigen with distinctive immunogenicity. NY-ESO-1 is a member of the cancer/testis (CT) family of human tumor-associated antigens. NY-ESO-1 is an attractive candidate tumor antigen for the development of immunotherapy for a wide variety of cancers. NY-ESO-1 is expressed in multiple types of tumors, but its normal tissue distribution is primarily limited to testis and ovary. In addition, NY-ESO-1 elicits frequent antibody responses in cancer patients that are accompanied by strong CD8+ T cell responses against HLA-A2-restricted epitopes. Therefore, both humoral and cellular immune responses can be mounted against NY-ESO-1.
NY-ESO-1 (E978)
Haga click en la imagen para agrandarla
NY-ESO-1 (E978): sc-53869. Western blot analysis of NY-ESO-1 expression in U266 nuclear extract.
NY-ESO-1 (E978): sc-53869. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferus ducts (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
