TRFP (E-18) Anticuerpo: sc-5382

TRFP Background Information
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Srb7 also interacts with an additional member of the RNAPII holoenzyme, the human homolog of Drosophila TBP-related factor (TRF)-proximal protein (TRFP) (5). TRFP synergistically associates with coactivators, including PC4 (positive coactivator 4) and USA (upstream stimulatory activity) of the RNAPII and SMCC complex, to enhance basal and gene-specific transcription (5,6).